High Fructose Corn Syrup: A Biotechnological Product in the Food Industry, Consumption and Impact

Authors

  • Marcela Alejandra Gloria Garza Autonomous University of Nuevo León image/svg+xml
  • Joel Horacio Elizondo Luévano Autonomous University of Nuevo León image/svg+xml
  • Juanita Guadalupe Gutiérrez Soto Autonomous University of Nuevo León image/svg+xml
  • Guillermo Cruz Palma Autonomous University of Nuevo León image/svg+xml
  • Carlos Jesús Castillo Zacarías Autonomous University of Nuevo León image/svg+xml

DOI:

https://doi.org/10.47633/3wb2g868

Keywords:

Corn starch, Sweetener, Metabolic diseases, Oral diseases, Fructose

Abstract

High fructose corn syrup (HFCS) is a liquid sweetener obtained through biotechnological processes in the food industry via enzymatic hydrolysis of corn starch, predominantly derived from genetically modified crops such as Bt corn (Bacillus thuringiensis). Its sweeter taste, low production cost, and wide availability have favored its massive incorporation into processed and ultra-processed foods and beverages since the 1970s, making it one of the main sources of sugars in the global diet. Several studies have shown that high and sustained consumption of HFCS is associated with an increased risk of metabolic and cardiovascular diseases, as well as alterations in the gut microbiota and the development of oral diseases. The World Health Organization has recommended limiting the intake of added sugars to less than 10% of total energy intake. The purpose of this review is to analyze its biotechnological origin, production processes, evolution of consumption and economic importance, and its implications for general and oral health.

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References

Referencias

Altuğ, T., Şen, G., & Kabakçı, R. (2024). Different concentrations of high fructose corn syrup in broiler diet cause different effects on selected hematological parameters. Tavukçuluk Araştırma Dergisi, 21(1), 22–26. https://doi.org/10.34233/jpr.1507530

Aoyagi, T., Ohira, G., Hayano, K., Martin, O., & Takabe, K. (2025). High-fructose corn syrup on inflammation and cancer. World Journal of Oncology, 16(6), 531–537. https://doi.org/10.14740/wjon2652

Arshad, S., Rehman, T., Saif, S., Rajoka, M. S. R., Ranjha, M. M. A. N., Hassoun, A., Cropotova, J., Trif, M., Younas, A., & Aadil, R. M. (2022). Replacement of refined sugar by natural sweeteners: Focus on potential health benefits. Heliyon, 8(9), e10711. https://doi.org/10.1016/j.heliyon.2022.e10711

Briones-Avila, L. S., Moranchel-Hernández, M. A., Moreno-Riolobos, D., Silva Pereira, T. S., Ortega Regules, A. E., López, K. V., & Islas Romero, L. M. (2021). Analysis of caloric and noncaloric sweeteners present in dairy products aimed at the school market and their possible effects on health. Nutrients, 13(9), 2994. https://doi.org/10.3390/nu13092994

Hattori, H., Hanai, Y., Oshima, Y., Kataoka, H., & Eto, N. (2021). Excessive intake of high-fructose corn syrup drinks induces impaired glucose tolerance. Biomedicines, 9(5), 541. https://doi.org/10.3390/biomedicines9050541

İlhan, İ., Ascı, H., Buyukbayram, H. İ., Imeci, O. B., Sevuk, M. A., Erol, Z., Aksoy, F., & Milletsever, A. (2024). The impact of high-fructose corn syrup on cardiac damage via SIRT1/PGC1-α pathway: Potential ameliorative effect of selenium. Biological Trace Element Research. Advance online publication. https://doi.org/10.1007/s12011-024-04081-z

Jung, S., Bae, H., Song, W. S., & Jang, C. (2022). Dietary fructose and fructose-induced pathologies. Annual Review of Nutrition, 42, 45–66. https://doi.org/10.1146/annurev-nutr-062220-025831

Şen, G., Demirci, M., Evci, Ş., Şenol, A., & Karsli, M. A. (2024). Effects of high-fructose corn syrup addition to broiler diets on performance, carcass yield, visceral weights, gut pH and some blood parameters. Veterinary Medicine and Science, 10(6), e70058. https://doi.org/10.1002/vms3.70058

Shkembi, B., & Huppertz, T. (2023). Impact of dairy products and plant-based alternatives on dental health: Food matrix effects. Nutrients, 15(6), 1469. https://doi.org/10.3390/nu15061469

Simsek, Y., Topaloğlu, U. S., & Dizdar, O. S. (2021). High-fructose corn syrup effects on metabolic parameters and malignancy. Journal of Diabetology, 12(3), 246–251. https://doi.org/10.4103/jod.jod_49_20

Published

2025-12-29

Issue

Section

Artículos (sección arbitrada)

How to Cite

High Fructose Corn Syrup: A Biotechnological Product in the Food Industry, Consumption and Impact. (2025). Revista Agro, 3(1), 1-14. https://doi.org/10.47633/3wb2g868

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